Figure 6

Area under the curve (AUC) for kaolin intake from time 0 to 120 hr. Methylnaltrexone significantly reduced kaolin intake induced by ritonavir (P < 0.01 compared to vehicle). Data are presented as mean ± SEM. RIT, ritonavir 20 mg/kg; MNTX0.3, methylnaltrexone 0.3 mg/kg; MNTX3.0, methylnaltrexone 3.0 mg/kg.