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Table 2 Summary of CD4 and CD8 T lymphocyte subset percentages for 19 IRIS cases and 19 matched controls at the time of diagnosis (IRIS cases) or enrollment (controls matched on ART duration)

From: Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)

T cell subset

Controls (n = 19)

Cases (n = 19)

p-value*

CD4 T lymphocytes ±

   

   CD4+

21.8 (17.2 – 32.5)

21.0 (14.4 – 25.5)

0.38

   CD27+ CD45RO- (N)

10.5 (8.44 – 25.3)

15.3 (3.07–25.8)

0.90

   CD27+ CD45RO+ (CM)

43.8 (31.3–55.7)

30.8 (13.9 – 50.0)

0.07

   CD27- CD45RO+ (EM)

27 (13.2 – 42.8)

40.8 (23.9 – 58.9)

0.20

   CD57+ CD45RO- (TE)

0.37 (0.1 – 1.4)

0.38 (0.18 – 2.76)

0.58

   CD57+ CD45RO+ (E)

3.99 (1.94 – 10.7)

6.03 (2.63 – 22)

0.17

CD8 T lymphocytes ±

   

   CD8+

70.2 (60.1 – 77)

68.3 (60.5 – 77.4)

0.90

   CD27+ CD45RO- (N)

13.3 (9.9 – 17.9)

18.5 (10.3 – 26.6)

0.23

   CD27+ CD45RO+ (CM)

13.9 (10.4 – 22.6)

7.81 (3.46 – 12.7)

0.01

   CD27- CD45RO+ (EM)

29 (22.7 – 36.1)

20.2 (9.0 – 31.7)

0.08

   CD57+ CD45RO- (TE)

15.1 (12.1 – 30.8)

28.8 (18.0 – 42.0)

0.05

   CD57+ CD45RO+ (E)

13.2 (7.6 – 24.5)

8.8 (5.5 – 10.7)

0.04

  1. All values determined by manual gating as detailed in methods. All values expressed as median percentage (Interquartile Range) unless otherwise noted. * p-values for comparison of case/control groups using Wilcoxon rank sum test; <0.05 considered significant. ±N: Naïve; CM: Central Memory; EM: Effector Memory; TE: Terminal Effector; E: Effector