Figure 1
From: HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction
HIV-1 transgene expression decreased glutathione levels and altered the glutathione redox balance in the alveolar space. Lung lavage fluid from HIV-1 transgenic (HIV-1 Tg) rats had significantly decreased (* P = 0.0016) levels of glutathione (GSH) as shown in panel A, and significantly increased (* P = 0.0049) ratios of glutathione disulfide (GSSG; the predominant form of oxidized glutathione) to GSH as shown in panel B, when compared to lung lavage fluid from wild type (WT) rats. The levels of GSH and GSSG were determined by HPLC as described in the Methods. Each value represents the mean ± SEM of 4 rats.