Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance

Table 3 Suboptimal CD4 reconstitution and clinical events among patients with sustained viral suppression in the infectious.

Duration of HAART	0–6 months (N = 380)			6–12 months (N = 339)			12–24 months (N = 309)
Variable	Suboptimal response	Optimal response	P value	Suboptimal response	Optimal response	P value	Suboptimal response	Optimal response	P value
i)SO-CD4 magnitude definition	78(21%)	302(79%)		151(45%)	188(55%)		166(54%)	143(46%)
OI events	11(14%)	77(25%)	0.04	14(9%)	9(5%)	0.13	8(5%)	4(3%)	0.40
ii)Threshold definition	165(43%)	215(57%)		143(42%)	196(58%)		58(18%)	309(82%)
OI events	49(30%)	66(31%)	0.90	11(8%)	12(6%)	0.66	1(0%)	11(8%)	0.70
iii) Definitions i & ii combined	56(15%)	324(85%)		129(38%)	213(62%)		3(1%)	306(99%)
OI events	8(10%)	80(26%)	0.12	9(6%)	14(7%)	0.36	2(1%)	11(8%)	0.70

Diseases Institute research cohort: we defined suboptimal CD4 reconstitution as i) CD4 count increase of either of a) less than 50 CD4 cells/μl at 6 months [6] b) <100 cells/μl in the first year of therapy [10] and c) <200 cells/μl after 2 years of HAART; ii) CD4 T cell threshold of <200 cells/μl.

ISSN: 1742-6405