Schematic representation of siRNA SB constructs. A) Control SB transposon plasmid construct with Neo resistance and RFP reporter genes. RFP is driven by a CMV promoter whereas the Neo resistance is expressed via IRES. B) SB transposon construct incorporating anti-CXCR4 siRNA driven by Pol III U6 promoter. C) SB transposon construct incorporating anti-CCR5 siRNA driven by Pol III H1 promoter. D) Plasmid construct encoding the hyperactive transposase under CMV promoter.