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Figure 1 | AIDS Research and Therapy

Figure 1

From: Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

Figure 1

Schematic representation of siRNA SB constructs. A) Control SB transposon plasmid construct with Neo resistance and RFP reporter genes. RFP is driven by a CMV promoter whereas the Neo resistance is expressed via IRES. B) SB transposon construct incorporating anti-CXCR4 siRNA driven by Pol III U6 promoter. C) SB transposon construct incorporating anti-CCR5 siRNA driven by Pol III H1 promoter. D) Plasmid construct encoding the hyperactive transposase under CMV promoter.

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