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Table 1 Screening of Various CDK and NFkB/IKK Inhibitors and Related Molecules for HTLV-1 Cell Killing

From: Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways

Selectivity Name MT-2 MT-4 C8166 C10/MJ CEM Jurkat Reported activities of molecules (IC50 in nM)
    Infected Uninfected  
High BMS-345541 (10 uM) ++++* +++ +++ + - ** - IKK-1(4), IKK-2(0.3)
  Purvalanol A (10 uM) ++++ ++ ++ - - - CDK1(4), CDK2(70), CDK5(75)
  Indirubin-3'-monoxime (10 uM) +++ +++ +++ +++ ++ ++ CDK1(180), CDK2(250), CDK4(3330), CDK5(100)
  Indirubin-3'-monoxime-5'-Iodo (10 uM) +++ +++ +++ +++ ++ ++ CDK1(25), CDK5(20)
  9-Cyanopaullone (10 uM) ++++ + - - - - CDK1(24), CDK5(44)
  Aloisine A (10 uM) +++ + - - - - CDK1(150), CDK2(120), CDK5(200)
  Compound 52 (10 uM) +++ + - - - - CDK1(340)
  Flavopiridol (0.1 uM) ++ + - - - - CDK9(50)
Moderate r-Roscovitine (10 uM) ++ - - - - - CDK1(650), CDK2(700), CDK5(160), CDK7(500)
  Bohemine (10 uM) ++ - - - - - CDK1(1000)
  s-Roscovitine (10 uM) + - - - - - CDK1(650), CDK2(700), CDK5(160), CDK7(500)
  WHI-P180 (10 uM) + N/A N/A - N/A N/A CDK2(1000)
  Kenpaullone (10 uM) + - - - - - CDK1(400), CDK2(680), CDK5(850)
  2,6-Diaminopurine (10 uM) - + - - - -  
  Flavone (10 uM) + - - - - - CDK1(300), CDK2(100), CDK4(400), CDK7(300)
  Alsterpaullone (10 uM) ++++ ++ +++ + ++ ++ CDK1(35), CDK2(15), CDK5(40)
  CGP 74514A (10 uM) ++++ ++ +++ + ++ ++ CDK1(25)
  BAY 11-7085 (10 uM) + ++++ +++ N/A ++++ ++++  
  BAY 11-7082 (10 uM) + ++++ +++ N/A ++++ ++++ IkBa(10000)
  CAPE (10 uM) + +++ - N/A ++++ ++++  
  Diethylmaleate (10 uM) + +++ - N/A ++++ ++++  
  Parthenolide (10 uM) + +++ +++ N/A ++++ ++++  
  Pyrrolidinedithiocarbamic acid (10 uM) - +++ +++ N/A ++++ ++++  
  Wedelolactone (10 uM) + ++ - N/A ++ ++  
Poor 6-Benzyloxypurine (10 uM) - - - - - -  
  5-amino alicylic acid (10 uM) - - - N/A - -  
  2,6-Dichloropurine (10 uM) - - - - - -  
  6-Dimethylaminopurine (10 uM) - - - - - - CDC
  Indirubin-3'-monoxime-5'-sulphonic acid (10 uM) - - - - - - CDK1(5), CDK5(7)
  Iso-olomoucine (10 uM) - - - - - - CDK1(>500,000), CDK4,5(>1,000,000)
  N-6-(Δ2-Isopentyl)-adenine (10 uM) - - - - - - CDK1,2,5(>50,000)
  Olomoucine (10 uM) - - - - - - CDK1,2(7000), CDK5(3000)
  Olomoucine, N9-isopropyl (10 uM) - - - - - - CDK1(2000)
  SC-514 (10 uM) - - - - - - IKK-1(>200), IKK-2(11.2)
  QNZ (10 uM) - - - N/A ++ +  
  * positive sign indicates level of cell inhibition   Inhibition Percentage      
  ** negative sign indicates no cell inhibition   - 1–5%      
    + 25%      
    ++ 50%      
    +++ 75%      
    ++++ 90%