Adipose tissue in mice treated with ritonavir. Male and female LDL-R null mice were administered ritonavir (15 μg/day) or vehicle (0.01% ethanol) through the drinking water for six weeks. At the conclusion of the study, epicardial and abdominal adipose tissue was removed and weighed. Data is expressed as a percentage of final body weight. Bars represent the mean +/- SEM, n = 6–8. * = significantly different from ritonavir (p < 0.05). # = significantly different from males (p < 0.05).