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Table 2 Association of the level of baseline ZDV resistance mutations and viral failure after 12 weeks on HAART

From: Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)

 

d4T plus RTV group

ZDV plus 3TC plus RTV group

Level of baseline ZDV resistance mutation

RNA > 400 at week 12

(N = 19)

RNA ≤ 400 at week 12

(N = 26)

RNA > 400 at week 12

(N = 22)

RNA ≤ 400 at week 12

(N = 25)

Higha

14

19

9

19

Intermediateb

0

0

0

0

Lowc

1

3

4

2

None

4

4

9

4

P-valued

0.904

0.017

  1. a. At least codon 215.
  2. b. At least one of codons 41 and 210, but no high level mutation (none at codon 215).
  3. c. At least one of codons 67, 70 and 219, but no high or intermediate level mutations (none at codons 215, 41 or 210).
  4. d. Mantel-Haenszel test for trend.