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Table 6 Multivariate model for factors associated with rates of combination antiretroviral treatment changes

From: Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD)

 

Multivariate5

 
 

RR (95% CI)

p

Drug class combination

 

<0.001

d4T/3TC/NVP

1.00

...

with NNRTI, no PI

1.64 (1.38 – 1.96)

<0.001

with PI, no NNRTI

3.39 (2.76 – 4.16)

<0.001

NRTI only

6.37 (4.51 – 9.00)

<0.001

Others

  

Combination 3

 

0.019 3

   First

1.00

...

   Second

0.82 (0.68 – 0.99)

0.035

   Third +

0.77 (0.61 – 0.97)

0.024

Number of drugs available 5

  

   > 12

1.00

...

   ≤ 12

1.31 (1.13 – 1.51)

< 0.001

Exposure

 

0.047

   Heterosexual

1.00

...

   IDU + others + unknown

1.24 (1.00 – 1.54)

0.055

   Homosexual

0.88 (0.73 – 1.07)

0.209

Income category

 

0.824

   Low income

1.00

...

   Lower middle Income

1.25 (0.98 – 1.56)

0.068

   Upper middle high income

1.06 (0.85 – 1.33)

0.581

Calendar year

  

   ≥ 2003

1.00

...

   ≤ 1999 – 2002

1.13 (0.98 – 1.30)

0.086

  1. 1 Estimated univariate Relative rates (RR) from random effects Poisson model may not equal ratio of crude rates
  2. 2 p from test for trend
  3. 3 Second and third combinations included patients who were not on combination treatment
  4. 4 Total number of drugs that have been used in TAHOD patients at the site where patients were receiving care
  5. 5 Variables included in the final multivariate model are presented in bold. All other non-significant variables are also presented adjusted for the variables included in the final multivariate model.
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AIDS Research and Therapy

ISSN: 1742-6405

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