Table 4 Toxicities reported as reason for first treatment change before and after 6 months, by treatment (n = 129)
Treatment (%) | ||||||
|---|---|---|---|---|---|---|
Reasons | d4T/3TC/NVP | with NNRTI, no PI | with PI | |||
≤ 6 mths | > 6 mths | ≤ 6 mths | > 6 mths | ≤ 6 mths | > 6 mths | |
Others | 6 (5) | 5 (4) | 9 (7) | 15 | 4 (3) | 6 (5) |
Lipoatrophy | 0 (0) | 19 (15) | 0 (0) | 6 | 0 (0) | 1 (0.8) |
Rash | 7 (5) | 1 (0.8) | 2 (1.6) | 0 (0) | 3 (2) | 0 (0) |
Anemia | 0 (0) | 0 (0) | 7 (5) | 0 (0) | 2 (1.6) | 0 (0) |
Hepatitis | 5 (4) | 2 (1.6) | 1 (0.8) | 0 (0) | 0 (0) | 0 (0) |
GI symptoms | 1 (0.8) | 0 (0) | 2 (1.6) | 0 (0) | 4 (3) | 0 (0) |
Lactic acidosis and hyperlactatemia | 0 (0) | 3 (2) | 0 (0) | 2 | 1 (0.8) | 1 (0.8) |
Metabolic Disturbance | 0 (0) | 1 (0.8) | 0 (0) | 3 | 0 (0) | 1 (0.8) |
Peripheral neuropathy | 1 (0.8) | 0 (0) | 1 (0.8) | 3 | 0 (0) | 0 (0) |