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Table 1 Demographic, clinical, and immunological data in association with the ARV treatment regimens

From: Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study

Parameters

ARV treatment regimens

 

NRTI+NNRTI+PI

(n = 15)

NRTI+NNRTI

(n = 6)

NRTI + PI

(n = 13)

NRTIs

(n = 7)

Age of study entry (Mean+/-SD, yrs)

11.9+/-4.3

10.8+/-3.4

8.8+/-5.1

10.4+/-3.0

Length of treatment (Mean+/-SD, yrs)

7.8+/-3.1

6.7+/-2.3

5.1+/-2.8

5.8+/-2.7

Number of Medications

    

NRTI

3.7+/-0.7

3.3+/-1.0

3.1+/-1.0

2.7+/-1.1

NNRTI

1.1 +/-0.2

1.2+/-0.4

-

-

PI

1.1+/-0.6

-

1.2+/-0.4

-

Clinical categories *

    

B

8 (53.3%)

3/5 (60.0%)

4 (30.8%)

3 (42.9%)

C

7 (46.7%)

2/5 (40.0%)

9(69.2%)

4 (57.1%)

Immune categories **

    

1 (no suppression)

10 (66.3%)

4 (66.7%)

7 (53.9%)

3 (42.9%)

2–3 (moderate/severe)

7 (33.3%)

2 (33.3%)

6 (46.1%)

4 (57.1%)

PVL (n, %)

    

<10,000

5 (33.3%)

4 (66.7%)

2 (15.4%)

4 (57.1%)

≥ 10,000

10 (66.7%)

2 (33.3%)

11 (84.6%)

3 (42.9%)

Number of mutations (Mean+/-SD)

5.7+/-3.8

3.5+/-1.6

4.7+/-3.2

3.7+/-2.3

  1. *B-moderately, C-severely symptomatic 22,23
  2. ** Immune categories based on age-specific CD4+ T-lymphocyte count.22,23