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Table 2 Performance of algorithms using TLCs alone or in combination with Hb and BMI in predicting CD4 cell counts ≤ 350 cells/μL in the Home-Based AIDS Care project, Tororo, Uganda

From: Determining eligibility for antiretroviral therapy in resource-limited settings using total lymphocyte counts, hemoglobin and body mass index

TLC Lower threshold

TLC Upper threshold

Hb threshold

BMI threshold

Sensitivity for CD4 <350

Specificity for CD4 <350

accuracy

sensitivity for CD4<200

False Positives

N Qualifying For ART

A) CD4 alone

   

1.00

1.00

1.00

1.00

0

1230

B) TLC alone

1500

   

0.40

0.95

0.67

  

519

1750

   

0.59

0.85

0.67

0.69

0.11

801

2000

   

0.71

0.69

0.71

0.80

0.17

1043

*2250

   

0.81

0.54

0.73

0.88

0.21

1250

2500

   

0.88

0.41

0.73

0.93

0.24

1404

2750

   

0.92

0.28

0.72

0.96

0.27

1523

3000

   

0.95

0.21

0.71

0.97

0.28

1601

C) TLC combined with Hb and/or BMI

1750

2750

11

 

0.71

0.75

0.68

0.81

0.14

1017

1750

2750

12

 

0.78

0.62

0.73

0.86

0.18

1180

1750

2750

 

18

0.64

0.77

0.68

0.75

0.14

917

1750

2750

11

18

0.74

0.69

0.73

0.84

0.16

1087

*2000

3000

11

 

0.81

0.62

0.75

0.88

0.18

1212

2000

3000

12

 

0.85

0.51

0.74

0.94

0.21

1335

2000

3000

 

18

0.75

0.63

0.72

0.84

0.19

1138

**2000

3000

11

18

0.83

0.57

0.75

0.90

0.20

1268

1750

2500

11

 

0.69

0.76

0.72

0.79

0.14

989

1750

2500

12

 

0.79

0.61

0.73

0.84

0.20

1169

1750

2500

11

18

0.72

0.72

0.72

0.82

0.15

1045

2000

2750

11

 

0.79

0.62

0.74

0.86

0.18

1190

2000

2750

 

18

0.75

0.64

0.71

0.83

0.19

1128

2000

2750

11

18

0.81

0.57

0.74

0.89

0.20

1242

D) TLC combined with Hb and/or BMI for WHO stages I and II only

**2000

3000

11

 

0.80

0.62

0.74

0.93

0.19

1282

2000

3000

11

18

0.83

0.57

0.73

0.90

0.20

1328

E) TLC combined with Hb and/or BMI for men only

2000

3000

11

 

0.58

0.71

0.72

0.80

0.12

 

2000

3000

12

 

0.76

0.63

0.73

0.84

0.14

 

2000

3000

11

18

0.77

0.60

0.73

0.87

0.14

 

**2000

3000

12

18

0.80

0.57

0.75

0.89

0.15

 
  1. Models with the highest accuracy using TLC alone (*) and TLC and Hb +/- BMI (**)
  2. ‡ Includes offering ART to 333 subjects with WHO stage III disease of whom 46 had CD4 cell counts > 350 cells/μL.