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Table 1 Selective inhibition of TNF-alpha by LMP-420

From: LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells

CYTOKINE

LPS-Stimulated Release (pg/ml)

Percent Inhibition

 

Media Alone

+ LMP-420 (1 μM)

 

IL-1β

15, 829 ± 75

10,670 ± 271

33

IL-2

24 ± 0

18 ± 1

25

IL-4

582 ± 54

419 ± 13

28

IL-5

7 ± 3

3 ± 1

57

IL-6

16,512 ± 190

17,249 ± 103

0

IL-7

26 ± 1

24 ± 1

8

IL-8

17,160 ± 221

17,575 ± 262

0

IL-10

1,963 ± 17

1,766 ± 62

10

IL-12

51 ± 3

76 ± 4

0

IL-13

44 ± 2

33 ± 0

25

IL-17

80 ± 1

56 ± 1

30

G-CSF

2,861 ± 98

4,794 ± 803

0

GM-CSF

93 ± 6

63 ± 4

32

MCP-1

2,714 ± 132

143 ± 0

95

MIP-1β

19,554 ± 63

19,127 ± 520

2

IFN-γ

424 ± 4

262 ± 1

38

TNF-α

7,628 ± 112

654 ± 7

91