Figure 2
From: Post-exposure prophylaxis for SIV revisited: Animal model for HIV prevention
Plasma viral load levels in untreated and PMPA-treated macaques after intravenous inoculation with uncloned SIVmne. Group A were naïve untreated macaques. Macaques in group B (plus macaque 93043 in group D) received a 10-week PMPA treatment beginning 24 hours after virus inoculation, including treatment interruption plus SIVmne re-inoculation at weekly intervals during the first six weeks of treatment. Macaques in groups C and D received a 5-week PMPA treatment starting 24 hours after virus inoculation, including one treatment interruption plus SIVmne re-inoculation at week 1 of treatment. SIV RNA in plasma measurements were performed at Bayer Diagnostics (Berkeley, CA) using a branched DNA (bDNA) signal amplification assay for SIV. This bDNA assay has a lower-limit of detection of125 RNA copies/ml.