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Table 1 Variations in HLA-G DNA sequence observed among HIV-1-transmitting and non-transmitting mother-child pairs.

From: HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission

Exons Codons Nucleotide positions Nucleotide substitutions* Amino acid changes
5'URR --- 634 C/G C→G None
5'URR --- 714 ins T,G insT,G None
2 α-1-domain 31 1074 A/T A→T Thr-to-Ser
2 α-1-domain 57 1154 G/A G→A Pro-to-Pro
3 α-2-domain 93 1486 C/G C→G His-to-Asp
3 α-2-domain 93 1486 C/A C→A His-to-Asp
3 α-2-domain 93 1488 C/T C→T None (His)
3 α-2-domain 107 1528 G/A G→A Gly-to-Arg
3 α-2-domain 110 1537 C/A C→A Leu-to-Ile
3 α-2-domain 130 1597 del C del C Leu→frameshift
4 α-3-domain 256 2575 G/A G→A Arg-to-Lys
4 α-3-domain 257 2577 T/A T→A Tyr-to-Asn
4 α-3-domain 269 2614 C/A C→A Pro-to-His
4 α-3-domain 272 2622 C/A C→A Leu-to-Met
Intron 6   3401 ins C ins C None
Intron 7   3579 G/A G→A None
   3585 G/T G→T None
   3619 C/G C→G None
8 (3'UTR)   3742 T/A T→A instability of mRNA
8 (3'UTR)   3743 C/T Del 14 bp instability of mRNA
8 (3'UTR)   3777 G/C G→C instability of mRNA
  1. *Polymorphisms are indicated with reference to the wild-type HLA 6.0 sequence previously published by Geraghty (1987).