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Figure 8 | AIDS Research and Therapy

Figure 8

From: Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

Figure 8

Confocal microscopic images of suspended MT-2 cells incubated with R.I.CK(fluorescein)-Tat9 (A, B), PEG3.4 K-R.I.CK(fluorescein)-Tat9 (C, D) and PEG10 K- [R.I.CK(fluorescein)-Tat9]8 (E, F) for 24 hours (all 1μM relative to Tat9). (A, C and E show fluorescence images while B, D and F are light images generated by differential interference contrast (DIC) of the same fields. All focal planes are through the middle of the cells. A and C show bright intracellular fluorescence, while E shows primarily cell surface bound fluorescence.

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