Skip to main content
Figure 4 | AIDS Research and Therapy

Figure 4

From: Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

Figure 4

Synthetic scheme of Tat-SQV bioconjugates (i) 3 equivalents Fmoc-Cys(S-Trt)-COOH in CH2Cl2 with DIPC/DMAP; (ii) 20% piperidine in CH2Cl2 ; (iii) TFA/CH2Cl2 (1:1); (iv) 2 equivalents Fmoc-PEG3.4 K-NHS in CH2Cl2 with DIEA; (v) 2 equivalents 2,2'-Dithiodipyridine in DMSO; (vi) 2 equivalents. R.I.CK-Tat9 in DMSO.

Back to article page