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Table 3 Sensitivity of NRTI-resistant RTs to the DNA aptamer RT1t49Assays were performed as described previously [34]. Data represent mean ± SEM of three independent experiments.

From: HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

Enzyme

IC50, nM

Ratio

WT

1.5 ± 0.03

1

E89G

4.9 ± 0.06

3.3

K65R

8.0 ± 0.05

5.3

L74V

0.86 ± 0.02

0.6

M184V

3.2 ± 0.05

2.1

T215Y/M41L

2.1 ± 0.04

1.4

  1. aConcentration of inhibitor at which 50% of the activity was inhibited over the IC50 for wild type (WT) RT
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AIDS Research and Therapy

ISSN: 1742-6405

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