TY - JOUR AU - Aung, Han AU - Mehendale, Sangeeta AU - Chang, Wei-Tien AU - Wang, Chong-Zhi AU - Xie, Jing-Tian AU - Yuan, Chun-Su PY - 2005 DA - 2005/12/20 TI - Scutellaria baicalensis decreases ritonavir-induced nausea JO - AIDS Research and Therapy SP - 12 VL - 2 IS - 1 AB - Protease inhibitors, particularly ritonavir, causes significant gastrointestinal disturbances such as nausea, even at low doses. This ritonavir-induced nausea could be related to its oxidative stress in the gut. Alleviation of drug-induced nausea is important in effectively increasing patients' compliance and improving their quality of life. Conventional anti-emetic drugs can only partially abate the symptoms in these patients, and their cost has also been a concern. Rats respond to nausea-producing emetic stimuli by increasing consumption of non-nutritive substances like kaolin or clay, a phenomenon known as pica. In this study, we used this rat pica model to evaluate the effects of Scutellaria baicalensis, a commonly used oriental herbal medicine, on ritonavir-induced nausea. SN - 1742-6405 UR - https://doi.org/10.1186/1742-6405-2-12 DO - 10.1186/1742-6405-2-12 ID - Aung2005 ER -