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Table 5 Summary of pharmacokinetic parameters in the substudy

From: Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial

Pharmacokinetic parameters

Darunavir

Cobicistat

Emtricitabine

Tenofovir

n = 60

AUCtau, ng•h/ml [mean (SD)]

81,646 (26,322)*

7596 (3657)*

11,793 (3490)†

3613 (1203)†

Cmax, ng/ml [mean (SD)]

7663 (1920)

991 (331)

1862 (491)*

382 (118)*

Ctau, ng/ml [mean (SD)]

1311 (969)*

33 (95)*

113 (101)†

78 (33)†

C0h, ng/ml [mean (SD)]

1560 (1328)

76 (186)

147 (171)*

84 (45)*

Tmax, h [median (Q1, Q3)]

3.50 (2.49, 4.29)

3.50 (2.01, 4.50)

2.02 (2.00, 3.50)*

2.00 (1.00, 3.05)*

t1/2, h [median (Q1, Q3)]

7.24 (5.35, 11.54)‡

3.25 (2.91, 3.81)*

7.14 (6.44, 7.86)§

13.34 (11.68, 15.35)§

  1. *n = 59; †n = 58; ‡n = 55; §n = 56.