|
Pharmacokinetic parameters
|
Darunavir
|
Cobicistat
|
Emtricitabine
|
Tenofovir
|
|---|
|
n = 60
|
|---|
|
AUCtau, ng•h/ml [mean (SD)]
|
81,646 (26,322)*
|
7596 (3657)*
|
11,793 (3490)†
|
3613 (1203)†
|
|
Cmax, ng/ml [mean (SD)]
|
7663 (1920)
|
991 (331)
|
1862 (491)*
|
382 (118)*
|
|
Ctau, ng/ml [mean (SD)]
|
1311 (969)*
|
33 (95)*
|
113 (101)†
|
78 (33)†
|
|
C0h, ng/ml [mean (SD)]
|
1560 (1328)
|
76 (186)
|
147 (171)*
|
84 (45)*
|
|
Tmax, h [median (Q1, Q3)]
|
3.50 (2.49, 4.29)
|
3.50 (2.01, 4.50)
|
2.02 (2.00, 3.50)*
|
2.00 (1.00, 3.05)*
|
|
t1/2, h [median (Q1, Q3)]
|
7.24 (5.35, 11.54)‡
|
3.25 (2.91, 3.81)*
|
7.14 (6.44, 7.86)§
|
13.34 (11.68, 15.35)§
|
- *n = 59; †n = 58; ‡n = 55; §n = 56.
