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Table 5 Summary of pharmacokinetic parameters in the substudy

From: Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial

Pharmacokinetic parameters Darunavir Cobicistat Emtricitabine Tenofovir
n = 60
AUCtau, ng•h/ml [mean (SD)] 81,646 (26,322)* 7596 (3657)* 11,793 (3490) 3613 (1203)
Cmax, ng/ml [mean (SD)] 7663 (1920) 991 (331) 1862 (491)* 382 (118)*
Ctau, ng/ml [mean (SD)] 1311 (969)* 33 (95)* 113 (101) 78 (33)
C0h, ng/ml [mean (SD)] 1560 (1328) 76 (186) 147 (171)* 84 (45)*
Tmax, h [median (Q1, Q3)] 3.50 (2.49, 4.29) 3.50 (2.01, 4.50) 2.02 (2.00, 3.50)* 2.00 (1.00, 3.05)*
t1/2, h [median (Q1, Q3)] 7.24 (5.35, 11.54) 3.25 (2.91, 3.81)* 7.14 (6.44, 7.86)§ 13.34 (11.68, 15.35)§
  1. *n = 59; n = 58; n = 55; §n = 56.