Impact of second-line antiretroviral regimens on lipid profiles in an African setting: the DART trial sub-study

Table 1 Demographic data, BMI, CD4 count and plasma lipid levels at initiation of second-line ART (switch from first-line ART)

At switch to second-line	n (%)	TC mean (se)	^†P	LDL-C mean (se)	^†P	HDL-C mean (se)	^†P	TG mean (se)	^†P	TC/HDL-C ratio mean (se)	^†P
All	65	3.4 (0.1)		1.8 (0.1)		0.7 (0.03)		1.4 (0.1)		4.9 (0.2)
Sex
Females	31 (48%)	3.8 (0.2)	0.004	2.1 (0.2)	0.006	0.8 (0.04)	0.05	1.3 (0.1)	0.80	4.9 (0.2)	0.66
Males	34 (52%)	3.0 (0.1)		1.5 (0.1)		0.7 (0.04)		1.8 (0.2)		4.8 (0.3)
Age (years)
<35	17 (26%)	3.4 (0.2)	0.61	1.7 (0.2)	0.7	0.8 (0.1)	0.78	1.3 (0.3)	0.10	4.8 (0.4)	0.46
35-44	33 (51%)	3.4 (0.2)		1.9 (0.1)		0.7 (0.1)		1.5 (0.1)		4.9 (0.2)
≥45	15 (23%)	3.2 (0.4)		1.7 (0.2)		0.7 (0.1)		1.5 (0.3)		4.8 (0.3)
^¥BMI (kg/m²)
<18.5	10 (16%)	3.0 (0.3)	0.11	1.6 (0.2)	0.04	0.8 (0.1)	0.33	1.0 (0.3)	0.46	4.2 (0.4)	0.45
18.5-24.9	41 (67%)	3.4 (0.1)		1.8 (0.1)		0.7 (0.1)		1.6 (0.2)		4.9 (0.2)
25-29.9	8 (13%)	3.4 (0.3)		1.8 (0.2)		0.7 (0.1)		1.4 (0.2)		4.8 (0.2)
30-39.9	2 (3%)	4.0 (0.1)		2.4 (0.1)		0.7 (0.1)		1.7 (0.9)		5.5 (0.5)
CD4 cell/mm³
<100	57 (88%)	3.3 (0.1)	0.95	1.7 (0.1)	0.47	0.7 (0.02)	0.64	1.5 (0.1)	0.85	4.8 (0.2)	0.73
100-199	6 (9%)	3.9 (0.9)		2.1 (0.6)		0.7 (0.1)		1.4 (0.2)		6.0 (1.0)
≥200	2 (3%)	4.0 (0.6)		2.2 (0.7)		1.2 (0.1)		0.6 (0.2)		3.5 (0.8)
ART-during first-line
ZDV/d4T + 3TC + TDF	56 (86%)	3.4 (0.1)	0.59	1.8 (0.1)	0.30	0.7 (0.03)	0.02	1.5 (0.1)	0.04	5.0 (0.2)	0.09
^±ZDV/d4T++NVP	9 (14%)	3.4 (0.2)		1.9 (0.2)		0.9 (0.10)		0.9 (0.1)		4.0 (0.4)

^†P-values for continuous BMI, Age and CD4 vs lipids calculated using Spearman correlation.
^¥4 participants with missing weight at initiation of second –line ART.
^±Including 3 patients who had substituted NVP- > TDF for hepatotoxicity (2) or anti-TB therapy (1) during first-line.
TC: total cholesterol, LDL-C: low density lipoprotein–cholesterol, HDL-C: high density lipoprotein–cholesterol, TG: triglyceride, BMI: Body mass index. All lipid levels are expressed in mmol/L.

ISSN: 1742-6405