Skip to main content

Table 4 The frequency of major drug resistance mutations and resistance complexes associated with PIs, NRTIs and NNRTIs of the 89 genotyped patients

From: Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort

  NNRTI-based regimen (n = 73) PI-based regimen (n = 16)
NNRTI mutations Number Percentage Number Percentage
Any NNRTI DRM 60 82.2 4 25.0
L100I 5 6.9 0 0
K101EP 6 8.2 0 0
K103NRS 46 63.0 2 12.5
V106M 23 31.5 2 12.5
V108I 7 9.6 1 6.3
Y181C 2 2.7 0 0
Y188HCL 7 9.6 1 6.3
G190AS 9 12.3 1 6.3
P225H 14 19.2 0 0
M230L 3 4.1 0 0
NRTI mutations     
Any mutation 63 86.3 10 62.5
M41L 7 9.6 0 0
K65NR 4 5.5 1 6.3
D67NG 8 11.0 0 0
K70ER 7 9.6 0 0
L74VI 4 5.5 1 6.3
Y115F 3 4.1 2 12.5
M184VI 60 82.2 10 62.5
L210W 1 1.4 0 0
T215FYI 9 12.3 0 0
K219QREN 5 6.9 0 0
Any TAMS 22 30.1 0 0
1 TAM 11 15.1 0 0
2 TAMs 7 9.6 0 0
≥3 TAMs 4 5.5 0 0
Q151M complex 1 1.4 1 6.3
PI mutations     
Any PI mutation 0 0 1 6.3
V82A 0 0 1 6.3