Table 4 The frequency of major drug resistance mutations and resistance complexes associated with PIs, NRTIs and NNRTIs of the 89 genotyped patients
From: Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort
NNRTI-based regimen (n = 73) | PI-based regimen (n = 16) | |||
|---|---|---|---|---|
NNRTI mutations | Number | Percentage | Number | Percentage |
Any NNRTI DRM | 60 | 82.2 | 4 | 25.0 |
L100I | 5 | 6.9 | 0 | 0 |
K101EP | 6 | 8.2 | 0 | 0 |
K103NRS | 46 | 63.0 | 2 | 12.5 |
V106M | 23 | 31.5 | 2 | 12.5 |
V108I | 7 | 9.6 | 1 | 6.3 |
Y181C | 2 | 2.7 | 0 | 0 |
Y188HCL | 7 | 9.6 | 1 | 6.3 |
G190AS | 9 | 12.3 | 1 | 6.3 |
P225H | 14 | 19.2 | 0 | 0 |
M230L | 3 | 4.1 | 0 | 0 |
NRTI mutations | ||||
Any mutation | 63 | 86.3 | 10 | 62.5 |
M41L | 7 | 9.6 | 0 | 0 |
K65NR | 4 | 5.5 | 1 | 6.3 |
D67NG | 8 | 11.0 | 0 | 0 |
K70ER | 7 | 9.6 | 0 | 0 |
L74VI | 4 | 5.5 | 1 | 6.3 |
Y115F | 3 | 4.1 | 2 | 12.5 |
M184VI | 60 | 82.2 | 10 | 62.5 |
L210W | 1 | 1.4 | 0 | 0 |
T215FYI | 9 | 12.3 | 0 | 0 |
K219QREN | 5 | 6.9 | 0 | 0 |
Any TAMS | 22 | 30.1 | 0 | 0 |
1 TAM | 11 | 15.1 | 0 | 0 |
2 TAMs | 7 | 9.6 | 0 | 0 |
≥3 TAMs | 4 | 5.5 | 0 | 0 |
Q151M complex | 1 | 1.4 | 1 | 6.3 |
PI mutations | ||||
Any PI mutation | 0 | 0 | 1 | 6.3 |
V82A | 0 | 0 | 1 | 6.3 |