Table 2 Characteristics of children on NNRTI-based and PI-based regimens (based on regimen at time of genotype)
From: Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort
NNRTI (n = 73) | PI (n = 16) | |
|---|---|---|
At ART initiation | ||
Age, years, median (IQR)** | 7.6 (5.2-10) | 1.5 (0.7-3.8) |
CD4+ cell count, cells/μl, median (IQR)* | 256 (108–477) | 647 (112–817) |
Viral load, log10 copies/ml, median (IQR) | 3.9 (3.7-4.2) | 4.7 (4.7-4.7) |
At Genotyping | ||
Age at genotyping, years, median (IQR) | 11.4 (8.9-13.4) | 5.0 (2.7-7.5) |
CD4+ cell count prior to genotyping, cells/μl, median (IQR)** | 379 (167–668) | 762 (603–1123) |
Viral load prior to genotyping, log10 copies/ml, median (IQR) | 4.3 (3.8-4.8) | 4.3 (3.8-5.2) |
Comparative measures | ||
Duration of ART, years, median (IQR) | 3.4 (2.6-4.5) | 2.7 (1.6-4.0) |
Duration of ART failure, years, median (IQR) | 1.8 (0.9-2.4) | 1.6 (0.8- 2.3) |
Time between last viral load and genotyping, months, median (IQR) | 3.3 (1.6-7.1) | 3.0 (1.1-4.85) |