Table 1 Demographic and clinical characteristics of the 89 children with a genotype
From: Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort
Characteristic | Outcome |
|---|---|
Gender, male, n (%) | 53 (59.6) |
At ART initiation | |
Age, years, median (IQR) | 7 (3.7-9.6) |
Number of children per age group n(%) | |
0-3 years | 17 (23) |
4-9 years | 37 (50) |
10-15 years | 20 (27) |
Viral load, log10 copies/ml, median (IQR) | 4.0 (3.7-4.7) |
CD4+ cell count, cells/μl, median (IQR) | 286 (112–560) |
By Age category: | |
0 - 2 yrs (n = 3) | 817 (31–1564) |
>2 – 5 yrs (n = 29) | 469 (194–619) |
>5 yrs (n = 38) | 200 (69–363) |
ART regimen, n (%) | |
d4T/3TC/EFV | 64 (71.9) |
d4T/3TC/LPVr | 12 (13.5) |
ABC/3TC/EFV | 8 (8.9) |
ABC/3TC/LPVr | 4 (4.5) |
AZT/3TC/EFV | 1 (1.1) |
At genotyping | |
Age, years, median (IQR) | 10.2 (7.7 – 12.9) |
Number of children per age group n(%) | |
0-3 years | 4 (4.5) |
4-9 years | 38 (42.7) |
10-15 years | 47 (52.8) |
Viral load prior to genotyping*, log10 copies/ml, median (IQR) | 4.2 (3.8-4.8) |
CD4+ cell count prior to genotyping*, cells/μl, | 460 (228–769) |
median (IQR) | |
By Age category: | 2339 (1621–2538) |
0 - 2 yrs (n = 4 ) | 685 (442–956) |
2 – 5 yrs (n = 37) | 295 (147–564) |
>5 yrs (n = 47) | |
ART regimen at time of genotyping, n (%) | |
d4T/3TC/EFV | 58 (65.2) |
d4T/3TC/LPVr | 8 (8.9) |
ABC/3TC/EFV | 14 (15.7) |
ABC/3TC/LPVr | 8 (8.9) |
AZT/3TC/EFV | 1 (1.1) |
Duration of ART, years, median (IQR) | 3.3 (2.5-4.4) |
Duration of ART failure†, years, median (IQR) | 1.8 (0.8-2.4) |
Time between last viral load and genotype, months, median (IQR) | 3.1 (1.4-7.0) |
History of ART substitution#, yes, n (%) | 12 (13.5) |