Table 3 Cellular expression levels (+ %) of immunological biomarkers in early- ART suppressed HIV-infected subjects a
n = 24 | ART time point 1 | ART time point 2 | P valuea | |
|---|---|---|---|---|
Gender | 58.30% | / | ||
Age | Years | 46 (42–48.7) | 48 (44–50) | / |
Length of time on ART | Months | 6.4 (4.8–13.9) | 29.3 (27.3–38.9) | / |
Viral Load | copies/mL | 75 (56.2–75) | 75 (56.2 - 75) | ns |
CD4+ T cells | Total (cells/uL) | 300.0 (222.5–360.7) | 425 (328.25–513.5) | <0.0001 |
CD8+ T cells | Total (cells/uL) | 1085 (710–1396) | 1114 (750.3–1593) | ns |
SSC++Lin- (+%) | CD11c+ mDCs (HLADR+CD11c+) | 3.9 (2.7–5.4) | 2.8 (2.3–4.4) | ns |
Classical Monocytes (HLADR+CD11c+CD14hiCD16-) | 70.3 (67.8–75.1) | 78.8 (74.35–83.1) | 0.004 | |
Non-Classical Monocytes (HLADR+CD11c+CD14dimCD16+) | 3.0 (1.6–6.2) | 3.8 (2.3–5.7) | ns | |
Classical Monocytes (HLADR+CD11c+CD14hiCD16-) | HLA-DR gMFI | 14375(10569–16546) | 12516 (10343–15220) | ns |
CD11b gMFI | 31139 (26954–34508) | 31096 (27432–34876) | ns | |
CD11c gMFI | 13514 (10406–14970) | 12069 (10430–13956) | 0.008 | |
CD33 gMFI | 29624 (20462–36580) | 29938 (19164–37687) | ns | |
Non-Classical Monocytes (HLADR+CD11c+CD14dimCD16+) | HLA-DR gMFI | 12311 (10047–14272) | 12993 (11328–14673) | ns |
CD11b gMFI | 2123 (1726–3767) | 2421 (1756–2957) | ns | |
CD11c gMFI | 21517 (17876–24957) | 22780 (20620–24761) | ns | |
CD33 gMFI | 8678 (6510–11084) | 8956 (6472–11433) | ns | |
CD14+ monocytes | HO-1 gMFI | 16290 (14784–18027) | 15785 (13875–18535) | ns |