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Table 2 Biomarkers in pre-ART suppressed subjects prior to and during suppressive ART a

From: Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4+ T cell recovery after the initiation of antiretroviral therapy for HIV disease

  n = 12 Pre-ART timepoint [Median (IQR)] Post-ART timepoint [Median (IQR)] P valuea
Gender   83.30% /
Age Years 46.5 (41.5–47) 49 (43.2–50) /
Viral Load copies/mL 33,123 (19,383–100,092) 75 (75–75) 0.03
CD4+ T cells Total (cells/uL) 173.5 (149.3–251.8) 435 (343.8–594.3) 0.0006
CD8+ T cells Total (cells/uL) 1320 (792–1630) 1561 (1105–2313) ns
Activation (+%) CD4+CD38+HLADR+ 13.0 (9.6–26.6) 3.6 (2.6–4.7) 0.0007
  CD8+CD38+HLADR+ 22.5 (13.9–24.1) 6.8 (5.2–10.2) 0.0007
SSC++Lin- (+%) Classical Monocytes (HLADR+CD11c+CD14hiCD16-) 54.1 (44.5–60.2) 69.2 (64.3–71.1) 0.0009
  Non-Classical Monocytes (HLADR+CD11c+CD14dimCD16+) 16.0 (11.1–20.3) 10.7 (8.1–12.9) 0.01
PBMC gene transcript expression HO-1/HPRT 142.5 (98.0–182) 78.8 (56.5–104.5) 0.05
  1. aPre-ART suppressed subjects were un-treated subjects with un-suppressed viral load.