Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4+ T cell recovery after the initiation of antiretroviral therapy for HIV disease

Table 2 Biomarkers in pre-ART suppressed subjects prior to and during suppressive ART ^a

	n = 12	Pre-ART timepoint [Median (IQR)]	Post-ART timepoint [Median (IQR)]	P value^a
Gender		83.30%		/
Age	Years	46.5 (41.5–47)	49 (43.2–50)	/
Viral Load	copies/mL	33,123 (19,383–100,092)	75 (75–75)	0.03
CD4⁺ T cells	Total (cells/uL)	173.5 (149.3–251.8)	435 (343.8–594.3)	0.0006
CD8⁺ T cells	Total (cells/uL)	1320 (792–1630)	1561 (1105–2313)	ns
Activation (+%)	CD4⁺CD38⁺HLADR⁺	13.0 (9.6–26.6)	3.6 (2.6–4.7)	0.0007
	CD8⁺CD38⁺HLADR⁺	22.5 (13.9–24.1)	6.8 (5.2–10.2)	0.0007
SSC⁺⁺Lin^- (+%)	Classical Monocytes (HLADR⁺CD11c⁺CD14^hiCD16^-)	54.1 (44.5–60.2)	69.2 (64.3–71.1)	0.0009
	Non-Classical Monocytes (HLADR⁺CD11c⁺CD14^dimCD16⁺)	16.0 (11.1–20.3)	10.7 (8.1–12.9)	0.01
PBMC gene transcript expression	HO-1/HPRT	142.5 (98.0–182)	78.8 (56.5–104.5)	0.05

^aPre-ART suppressed subjects were un-treated subjects with un-suppressed viral load.

ISSN: 1742-6405