The development of simple anthropometric measures to diagnose antiretroviral therapy-associated lipodystrophy in resource limited settings

Table 4 DXA-derived measurements of female participants on ART

Variable	Lipoatrophy*		P-value**	Lipohypertrophy***		P-value**
Variable	With n = 29 Median [IQR]	Without n = 143 Median [IQR]	P-value**	With n = 46 Median [IQR]	Without n = 126 Median [IQR]	P-value**
DXA-derived measures
Arm fat (%)	37.4 [30.8-44.1]	38.3 [31.8-47.1]	0.380	39.8 [31.5-48.3]	38.1 [31.7-45.1]	0.319
Lower limb fat (%)	37.6 [31.5-40.6]	43.4 [36.6-49.7]	0.001	39.2 [33.3-49.7]	41.8 [36.3-48.8]	0.761
Trunk fat (%)	34.7 [29.9-38.0]	35.1 [27.9-43.1]	0.719	37.9 [30.7-45.3]	34.4 [26.6-40.4]	0.019
Lower limb fat/ht (%)	23.6 [19.7-25.4]	27.4 [23.4-31.5]	0.001	25.4 [21.9-31.1]	26.5 [23.2-29.7]	0.631
Total limb fat/ht (%)	22.7 [20.8-27.0]	25.4 [22.0-29.9]	0.015	25.4 [20.8-31.1]	25.2 [21.8-29.1]	0.825
Lower limb fat/BMI (%)	1.3 [1.2-1.7]	1.6 [1.3-1.8]	0.049	1.4 [1.2-1.6]	1.6 [1.3-1.8]	0.019
Total limb fat/BMI (%)	1.3 [1.3-1.6]	1.5 [1.3-1.6]	0.193	1.3 [1.2-1.5]	1.5 [1.3-1.7]	0.006
Trunk fat/lower limb fat (%)	0.94 [0.76-1.15]	0.83 [0.66-0.96]	0.017	0.93 [0.80-1.10]	0.81 [0.66-0.94]	0.003
Trunk fat/ total limb fat (%)	1.0 [0.8-1.0]	0.9 [0.7-1.0]	0.045	0.93 [0.85-1.03]	0.85 [0.72-0.97]	0.003

*based on patient report, those with moderate or severe fat loss in 2 or more regions.
**Wilcoxon Rank-sum (Mann–Whitney) tests for continuous variables and chi-square tests for binary variables.
***based on patient report, those with moderate or severe fat gain in 2 or more regions.

ISSN: 1742-6405