Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model

Table 4 Predictors of Hepatitis C treatment among patients referred to the hepatology (n = 163) and HIV primary care models (n = 196) in unadjusted and adjusted analyses

Covariate	Unadjusted	P value	Adjusted	P value
	OR (95% CI)		OR (95% CI)
Hepatitis C treatment
(HIV primary care vs. hepatology model )	1.7 (1.0–2.9)	0.04	1.6 (0.9–2.8)	0.08
CD4+ cell count ¹
(≥400 vs. < 400 cells/mm³)	1.8 (1.1–3.03)	0.03	2.1 (1.2–3.6)	0.01
Having detectable HIV load
(≥400 vs. < 400 copies/mL)	0.5 (0.3–1.1)	0.09	0.6 (0.3–1.1)	0.09
On any psychiatry medications
(any vs. none)	0.6 (0.3–0.99)	0.04	0.5 (0.3–0.9)	0.02
Alanine aminotransferase levels
(≥63 vs. < 63U/L)	1.9 (1.2–2.9)	0.002	1.4 (0.8–2.3)	0.3
Any neuropsychiatry history
(yes vs. no)	0.7 (0.4–1.2)	0.17
Age - years
Per year increase	1.0 (0.9–1.03)	0.88
Sex - biological
(male vs. female)	1.2 (0.6–2.3)	0.65
Race
(white vs. non-white)	1.2 (0.6–2.5)	0.61
Ethnicity:
(non-hispanic vs. hispanic)	1.6 (0.2–13.4)	0.68
HIV risk factors
Men having sex with men	Reference
Heterosexual	1.6 (0.9–3.2)	0.14
Intravenous drug use	0.4 (0.1–3.6)	0.44
Hemophilia	1.3 (0.3–5.1)	0.68
Combination	1.1 (0.5–2.1)	0.86
Hepatitis C genotype ²
(1/4 vs. 2/3)	0.8 (0.4–1.5)	0.50
Liver biopsy scores ³
(Proportion F3-4 vs. F0-2)	1.2 (0.6–2.5)	0.55
Drugs or alcohol use within 3 months of
HCV evaluation⁴
(yes vs. no)	0.7 (0.4–1.3)	0.24
HCV load - log₁₀ copies/mL⁵
(>6.33 vs. ≤ 6.33)	0.8 (0.5–1.4)	0.46
Hemoglobin levels
(>14.1 vs. ≤ 1 4.1 g/dL)	1.5 (0.8–2.6)	0.13
Platelet count
(>139 vs. ≤ 139 - 1000/mm³)	1.3 (0.8–2.1)	0.31
INR levels
(>1.1 vs. ≤1.1)	0.5 (0.2–1.3)	0.16

¹CD4+ counts available in 150 of 163 patients in the hepatology model and in all patients in HIV primary care model.
² HCV genotype was not available in seven patients in hepatology model and one in HIV primary care model.
³ Liver biopsies: 70 in hepatology and 67 in HIV primary care models.
⁴ No data available in 47 patients in the hepatology model and in 9 patients in the HIV primary care model.
⁵ Two patients in the hepatology model had no available HCV viral load.

ISSN: 1742-6405