Table 3 Comparison of characteristics of the treated vs. untreated patients for hepatitis C according to clinic model
From: Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model
Clinic Model | Hepatology | HIV Primary care | ||||
|---|---|---|---|---|---|---|
Treated | Not treated | P | Treated | Not treated | P | |
(n = 26) | (n = 137) | (n = 48) | (n = 148) | |||
Median age - years (range) | 44 (27–62) | 45 (26–73) | 0.73a | 49 (19–61) | 48 ( 23–75) | 0.46a |
Sex: Male (%) | 23 (89) | 114 (83) | 0.50b | 38 (79) | 127 (86) | 0.27b |
Race | ||||||
White | 21 | 94 | 0.46c | 32 | 106 | 0.63c |
Black | 4 | 35 | 13 | 37 | ||
Other/unknown | 1 | 8 | 2 | 5 | ||
Ethnicity | ||||||
Hispanic | 5 | 30 | 0.64c | 7 | 19 | 0.59c |
Not-Hispanic | 19 | 102 | 41 | 16 | ||
Unknown | 2 | 5 | 0 | 3 | ||
HIV risk factors | ||||||
Gay/bisexual | 8 | 71 | 0.18c | 21 | 57 | 0.33c |
Heterosexual | 5 | 19 | 14 | 32 | ||
Intravenous drug use | 1 | 2 | 0 | 8 | ||
Hemophilia | 3 | 5 | 0 | 5 | ||
combination | 3 | 22 | 11 | 36 | ||
Other/unknown | 6 | 18 | 2 | 10 | ||
Median CD4+ cell count - cells/mm3 (range) | 375 (149–1179) | 371 (29–1025) | 0.68a | 522 (130–1142) | 388 (38–1612) | 0.005a |
Number of patients on HIV therapy (%) | 22 (85%) | 110 (80%) | 0.61b | 44 (92%) | 128 (87%) | 0.74b |
Number with undetectable HIV load (%) | 22 (85%) | 95 (69%) | 0.11b | 40 (83%) | 115 (78%) | 0.41b |
Hepatitis C genotype1 | ||||||
Genotype 1/4 | 19 | 106 | 0.32c | 39 | 119 | 0.90b |
Genotype 2/3 | 7 | 24 | 9 | 26 | ||
Median HCV load - log10 copies/mL (range)2 | 6.0 (5.1–7.7) | 6.3 (1.9–8.4) | 0.71a | 6.4 (3.01–7.6) | 6.4 (2.2–8.4) | 0.19a |
Liver biopsy scores | ||||||
F0-2 | 8 | 31 | 0.10c | 12 | 30 | 0.19c |
F3-4 | 9 | 28 | 13 | 26 | ||
unknown | 9 | 78 | 23 | 92 | ||
Any neuropsychiatry history – % | 17 (65%) | 83(61%) | 0.65b | 23(48%) | 96(65%) | 0.04b |
On any psychiatry medications - % | 11 (42%) | 64(47) | 0.68b | 15(31%) | 73(49) | 0.03b |
Drugs or alcohol use within 3months of HCV treatment consideration | ||||||
No | 12 | 59 | 0.55c | 32 | 83 | 0.15c |
Yes | 5 | 40 | 16 | 56 | ||
Unknown | 9 | 38 | 0 | 9 | ||
Median hemoglobin levels - g/dL (range) | 14.8 (11.1–16.9) | 14.7 (9–18.7) | 0.37a | 14.5 (12.1–16.6) | 14.2 (7.7–17.6) | 0.67a |
Median platelet count -1000/mm3 (range) | 178 (56–367) | 185 (44–531) | 0.47a | 224 (113–418) | 207 (41–548) | 0.18a |
Median ALT - U/L (range) | 71 (22–980) | 67 (20–488) | 0.56a | 64 (19–1087) | 56 (12–1280) | 0.25a |
Median INR (range) | 1.1 (0.9–1.4) | 1.1 (0.9–2.3) | 0.33a | 1.0 (0.9–1.2) | 1.0 (0.9–2.6) | 0.66a |