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Table 3 Comparison of characteristics of the treated vs. untreated patients for hepatitis C according to clinic model

From: Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model

Clinic Model Hepatology HIV Primary care
  Treated Not treated P Treated Not treated P
(n = 26) (n = 137)   (n = 48) (n = 148)  
Median age - years (range) 44 (27–62) 45 (26–73) 0.73a 49 (19–61) 48 ( 23–75) 0.46a
Sex: Male (%) 23 (89) 114 (83) 0.50b 38 (79) 127 (86) 0.27b
Race       
White 21 94 0.46c 32 106 0.63c
Black 4 35 13 37
Other/unknown 1 8 2 5
Ethnicity       
Hispanic 5 30 0.64c 7 19 0.59c
Not-Hispanic 19 102 41 16
Unknown 2 5 0 3
HIV risk factors       
Gay/bisexual 8 71 0.18c 21 57 0.33c
Heterosexual 5 19 14 32
Intravenous drug use 1 2 0 8
Hemophilia 3 5 0 5
combination 3 22 11 36
Other/unknown 6 18 2 10
Median CD4+ cell count - cells/mm3 (range) 375 (149–1179) 371 (29–1025) 0.68a 522 (130–1142) 388 (38–1612) 0.005a
Number of patients on HIV therapy (%) 22 (85%) 110 (80%) 0.61b 44 (92%) 128 (87%) 0.74b
Number with undetectable HIV load (%) 22 (85%) 95 (69%) 0.11b 40 (83%) 115 (78%) 0.41b
Hepatitis C genotype1       
Genotype 1/4 19 106 0.32c 39 119 0.90b
Genotype 2/3 7 24 9 26
Median HCV load - log10 copies/mL (range)2 6.0 (5.1–7.7) 6.3 (1.9–8.4) 0.71a 6.4 (3.01–7.6) 6.4 (2.2–8.4) 0.19a
Liver biopsy scores       
F0-2 8 31 0.10c 12 30 0.19c
F3-4 9 28 13 26
unknown 9 78 23 92
Any neuropsychiatry history – % 17 (65%) 83(61%) 0.65b 23(48%) 96(65%) 0.04b
On any psychiatry medications - % 11 (42%) 64(47) 0.68b 15(31%) 73(49) 0.03b
Drugs or alcohol use within 3months of HCV treatment consideration       
No 12 59 0.55c 32 83 0.15c
Yes 5 40 16 56
Unknown 9 38 0 9
Median hemoglobin levels - g/dL (range) 14.8 (11.1–16.9) 14.7 (9–18.7) 0.37a 14.5 (12.1–16.6) 14.2 (7.7–17.6) 0.67a
Median platelet count -1000/mm3 (range) 178 (56–367) 185 (44–531) 0.47a 224 (113–418) 207 (41–548) 0.18a
Median ALT - U/L (range) 71 (22–980) 67 (20–488) 0.56a 64 (19–1087) 56 (12–1280) 0.25a
Median INR (range) 1.1 (0.9–1.4) 1.1 (0.9–2.3) 0.33a 1.0 (0.9–1.2) 1.0 (0.9–2.6) 0.66a
  1. 1 In the hepatology model (7) and HIV primary care model (3) patients had no available genotype, all in untreated group, there were no patients with genotype #4 in treated groups.
  2. 2 Two patients in the untreated group in the hepatology model had no available HCV viral load.
  3. a Wilcoxon Rank-Sum Test.
  4. b Chi-square Test.
  5. c Fisher’s exact Test.