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Table 2 Characteristics of the patients treated for hepatitis C according to clinic model and treatment outcomes

From: Increasing Hepatitis C treatment uptake among HIV-infected patients using an HIV primary care model

Clinic model Hepatology HIV primary care P value
  (n = 26) (n = 48)  
Median age - years (range) 44 (27–62) 49 (19–61) 0.18a
Sex: Male (%) 23 (88) 38 (79) 0.32b
Race    
White 21 32 0.44c
Black 4 13
Other/unknown 1 3
Ethnicity    
Hispanic 5 7 0.12c
Not-Hispanic 19 41
Unknown 2 0
HIV risk factors    
Gay/bisexual 8 21 0.008c
Heterosexual 5 14
Intravenous drug use 1 0
Hemophilia 3 0
combination 3 11
Other/unknown 6 2
Median CD4+ cell count - cells/mm3 (range) 375 (149–1179) 522 (130–1142) 0.02a
Number with undetectable HIV load (%) 22 (85) 29 (83) 0.88b
Hepatitis C genotype2    
Genotype 1/4 19 39 0.42b
Genotype 2/3 7 9
Median HCV load - log10 copies/mL (range) 6.04 (5.1–7.7) 6.41 (3.0–7.6) 0.88a
Liver biopsy scores 1    
F0-2 8 12 0.37c
F3,4 9 23
Number with relapse after prior HCV treatment (%) 5 (19) 5 (11) 0.29b
Any neuropsychiatry history – % 17 (65) 23 (48) 0.15b
On any psychiatry medications - % 11 (42) 15 (31) 0.34b
Drugs or alcohol use within 3months of HCV treatment consideration    
No 12 32 0.0001c
Yes 5 16
Unknown 9 0
Median hemoglobin levels - g/dL (range) 14.8 (11.1–16.9) 14.5(12.1–16.6) 0.17a
Median platelet count -1000/mm3 (range) 178 (56–367) 224 (113–418) 0.01a
Median ALT - U/L (range) 71 (22–980) 64 (19–1087) 0.48a
Median INR (range) 1.1 (0.9–1.4) 1.0 (0.9–1.2) 0.69a
HCV treatment outcomes    
№ Patients with rapid viral response (%) 4 (15) 12 (25) 0.34b
№ Patients with complete early viral response (%) 9 (35) 26 (54) 0.11b
№ Patients with end of treatment response (%) 12 (46) 24 (50) 0.75b
№ Patients with sustained viral response (%) 9 (35) 21 (44) 0.45b
№ Patients who discontinued HCV therapy due to non-viral response (%) 8 (31) 9 (19) 0.24b
№ Patients who discontinued HCV therapy due to treatment-related side effects (%) 4 (15) 14 (29) 0.16b
№ Patients lost to follow-up (%) 2 (8) 4 (8) 0.92b
  1. 1 Liver biopsies were not performed in 2 and 6 patients with genotype 1 in the hepatology and HIV primary care models respectively.
  2. a Wilcoxon Rank-Sum Test.
  3. b Chi-square Test.
  4. c Fisher’s exact Test.