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Table 2 Associations of serum FGF-21 levels

From: Elevated serum fibroblast growth factor 21 levels correlate with immune recovery but not mitochondrial dysfunction in HIV infection

(a)
Variable (n) Log10Serum FGF-21, mean (SD) p value
Gender Male (26) 2.39 (0.40)  
  Female (6) 2.46 (0.48) 0.71
Ethnicity Caucasian (27) 2.44 (0.33)  
  Black African (5) 2.21 (0.72) 0.27
Current ART PI (7) 2.29 (0.26)  
  No PI (25) 2.43 (0.44) 0.43
Lifetime ART d-drugs (8) 2.38 (0.26)  
  No d-drugs (24) 2.41 (0.45) 0.86
  AZT (23) 2.44 (0.42)  
  No AZT (9) 2.30 (0.39) 0.41
Lipodystrophy Yes (10) 2.50 (0.27)  
  No (22) 2.36 (0.46) 0.39
Lipid-lowering therapy Yes (8) 2.32 (0.52)  
  No (24) 2.43 (0.38) 0.53
(b)
Variable   Correlation coefficient (r) p value
Age   −0.07 0.69
Duration of diagnosed HIV infection   −0.08 0.67
Duration of lifetime ART Total 0.12 0.50
  d-drug 0.01 0.97
  AZT 0.13 0.47
CD4 lymphocyte count Nadir −0.29 0.14
  Current 0.36 0.042
CD4 count gain (Current minus nadir) 0.45 0.016
Serum ALT   0.27 0.14
Plasma glucose   0.34 0.06
Serum lipids Total cholesterol −0.03 0.87
  HDL cholesterol 0.02 0.90
  Non-HDL cholesterol −0.06 0.75
Mitochondrial histochemistry COX defect (log10) −0.02 0.91
  1. (a) binary variables; (b) continuous variables. (PI, protease inhibitor; AZT, zidovudine; d-drug, dideoxynucleoside analogue; ART, anti-retroviral therapy; ALT, alanine transaminase; HDL, high density lipoprotein).
  2. Bold type indicates statistically significant associations.