From: Coregulation of HIV-1 dependency factors in individuals heterozygous to the CCR5-delta32 deletion
Significant higher Expression in CCR5-delta32 samples | ||||
---|---|---|---|---|
Gene | Function (link to HIV-1) | Beneficial effect for CCR5-delta32 carriers | Reference | |
Transm. | Repli. | |||
U2AF65 | Splicing factor (enhances with the polypyrimidine tract of the splicosome of several HIV-1 genes) | Unknown | [35] | |
CD30L | Regulation immune response (elevated CD30 levels during acute HIV-1 infection) | Unknown | [36] | |
PRKACB | Catalytic subunit of camp-dependent protein kinase (coexpression with the HDF GliPR) | Unknown | [37] | |
TAP | Antigen presentation (HIV-1 abrogates TAP mediated peptide transport to MHC I presentation) | Possible | [38] |