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Table 2 Clinical characteristics of HIV patients with or without chronic non HBV/HCV hepatitis at baseline visit**

From: Risk factors of chronic hepatitis in antiretroviral-treated HIV infection, without hepatitis B or C viral infection

Clinical parameters

Case

Control

p value

 

(n = 124)

(n = 124)

 

Male sex (n,%)

65(52.4)

37(29.8)

0.001*

Mean age (years), ± SD

32.7 ± 7.4

33.3 ± 7.2

0.56

o ≤ 25 (n,%)

16(12.9)

12(9.7)

0.85

o 25–34.9 (n,%)

68(54.8)

70(56.4)

 

o 35–44.9 (n,%)

31(25.0)

34(27.4)

 

o ≥ 45 (n,%)

9(7.3)

8(6.5)

 

BMI ≥ 23 kg/m2 (n,%)

39(31.4)

27(21.8)

0.09

Elevated blood pressure/ hypertension (n,%)

18(14.5)

18(14.5)

1.00

Metabolic syndrome (n,%)

9(7.3)

3(2.4)

0.08

Sexual risk behavior (n,%)

  

0.08

o Heterosexual

83(66.9)

98(79.0)

 

o MSM

37(29.9)

23(18.6)

 

o Others

4(3.2)

3(2.4)

 

CDC classification (n,%)

  

0.21

o Category A or B

110(88.7)

117(94.4)

 

o Category C

14(11.3)

7(5.6)

 

Laboratory measurement (n,%)

   

o CD4+ cell count ≤ 200 cells/mm3

53(42.7)

50(40.3)

0.66

o Nadir CD4+ cell count ≤ 200 cells/mm3

67(54)

67(54)

1.00

o HIV-1 RNA level ≥ 5 log 10 copies/ml

41(33.1)

31(25)

0.13

o Impaired fasting plasma glucose ≥ 100 mg/dL

21(16.9)

16(12.9)

0.87

o Total cholesterol ≥ 200 mg/dL

25(22.7)

27(24.1)

0.87

o Triglycerides ≥ 150 mg/dL

25(22.7)

26(23.2)

0.88

o HDL cholesterol ≤ 40 mg/dL (male) or ≤ 50 mg/dL (female)

55(51.4)

57(52.3)

0.70

o LDL cholesterol ≥ 130 mg/dL

2(1.8)

1(0.9)

0.57

Median, duration of study (years) (IQR)

9.6(6.7–11.9)

9.6(6.7–11.9)

0.97

  1. Abbreviation: HIV Human immunodeficiency virus, HBV Hepatitis B virus, HCV Hepatitis C virus, SD Standard deviation, BMI Body mass index, MSM Men who have sex with men, CDC The centers for disease control and prevention, HDL Cholesterol High density lipoprotein cholesterol, LDL Cholesterol Low density lipoprotein cholesterol and IQR Interquartile range.
  2. *Significant value with p value less than 0.05.
  3. **Chronic hepatitis was defined as those with elevated ALT ≥ 40 IU/L at 2 consecutive visits 6 months apart.