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Table 3 Summary of susceptibility and phenotypic properties of V2, V3 and V4 single, double and triple mutants against vicriviroc

From: Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance

Loop

Mutant

Tropism

IC50

IC50

MPI

FC increase

Parental clone

Wild type

R5

1.56 nM

-

-

V2

V169M

R5

1.61 nM

1.03

100%

V3

L317W

R5

1.90 nM

1.21

100%

V4

I408T

R5

3.16 nM

2.02

94%

V2-V3

V169M

R5

1.56 nM

1.57

100%

L317W

V2-V4

V169M

R5

1.62 nM

1.03

96%

I408T

V3-V4

L317W

R5

1.68 nM

1.07

93%

I408T

V2-V3-V4

V169M

R5

1.59 nM

1.01

94%

 

L317W

I408T

  1. IC50, 50% effective concentration or concentration needed to inhibit 50% of HIV. IC50 FC was calculated as the ratio IC50 for resistant virus/IC50 for wild type virus. MPI (maximum percent inhibition) was calculated as described in Methods.