Loop | Mutant | Tropism | IC50 | IC50 | MPI |
---|---|---|---|---|---|
FC increase | |||||
Parental clone | Wild type | R5 | 1.47 nM | - | - |
V2 | V169M | R5 | 1.82 nM | 1.23 | 96% |
V3 | L317W | R5 | 2.24 nM | 1.52 | 95% |
V4 | I408T | R5 | 5.46 nM | 4.00 | 85% |
V2-V3 | V169M | R5 | 1.92 nM | 1.30 | 94.3% |
L317W | |||||
V2-V4 | V169M | R5 | 5.76 nM | 4.00 | 84% |
I408T | |||||
V3-V4 | L317W | R5 | 4.29 nM | 3.00 | 85% |
I408T | |||||
V2-V3-V4 | V169M | R5 | 4.88 nM | 3.31 | 83% |
L317W | |||||
I408T |