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Table 2 Susceptibility and phenotypic properties of V2, V3 and V4 single, double and triple mutants against maraviroc

From: Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance

Loop

Mutant

Tropism

IC50

IC50

MPI

FC increase

Parental clone

Wild type

R5

1.47 nM

-

-

V2

V169M

R5

1.82 nM

1.23

96%

V3

L317W

R5

2.24 nM

1.52

95%

V4

I408T

R5

5.46 nM

4.00

85%

V2-V3

V169M

R5

1.92 nM

1.30

94.3%

L317W

V2-V4

V169M

R5

5.76 nM

4.00

84%

I408T

V3-V4

L317W

R5

4.29 nM

3.00

85%

I408T

V2-V3-V4

V169M

R5

4.88 nM

3.31

83%

 

L317W

I408T

  1. IC50, 50% effective concentration or concentration needed to inhibit 50% of HIV. IC50 FC was calculated as the ratio IC50 for resistant virus/IC50 for wild type virus. MPI (maximum percent inhibition) was calculated as described in Methods.