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Table 1 Summary of sequence changes in env gene associated with decreased susceptibility to MVC and VCV in passages experiments

From: Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance

Virus, drug

Passage no.

gp 120 V2 loop amino acid sequence

CC1/85

start

158                        198

SFNITTSIRNKVQKQYALFYKLDVVPIDNDSNNTNYRLISC

CC1/85 control

4

------------------------------------------------------------------------

CC1/85, maraviroc

4

--------------------M--------------------------------------------K-------

CC1/85, vicriviroc

4

--------------------M------------------------------------------------------

CC1/85 control

16

-----------------------------------------------------------------------------

CC1/85, maraviroc

16

--------------------M--------------------------------------------K-------

CC1/85, vicriviroc

16

--------------------M------------------------------------------------------

  

gp 120 V3 loop amino acid sequence

CC1/85

start

296                        331

CTRPNNYTRKSIHIGPGRALYATGDIIGDIRQAHC

CC1/85 control

4

-----------------------------------------------------------------

CC1/85, maraviroc

4

-----------------------------------W--------------------------

CC1/85, vicriviroc

4

-----------------------------------W--------------------------

CC1/85 control

16

-----------------------------------------------------------------

CC1/85, maraviroc

16

-----------------------------------W--------------------------

CC1/85, vicriviroc

16

-----------------------------------W---------------------------

  

gp 120 V4 loop amino acid sequence

CC1/85

start

385                        418

CNSTKLFNSTWTWNNSTWNNTKRANDIEEIITLPC

CC1/85 control

4

--------------------------------------------------------------------

CC1/85, maraviroc

4

-----------------------------------------------------A-------------

CC1/85, vicriviroc

4

---------------------------------------------------------------------

CC1/85 control

16

-----------------------------------------------------A-------------

CC1/85, maraviroc

16

-----------------------------------------------------T--------------

CC1/85, vicriviroc

16

--------------------------------------------------------------------

  

gp 120 V5 loop amino acid sequence

CC1/85

start

461                        469

KDNSTNEIFR

CC1/85 control

4

-----------------

CC1/85, maraviroc

4

TN--T----N---

CC1/85, vicriviroc

4

-------------------

CC1/85 control

16

---------------

CC1/85, maraviroc

16

TNTT-D----

CC1/85, vicriviroc

16

-------------

  

gp 41 amino acid sequence

CC1/85

start

642                        681

IYNLLEESQNQQEKNEQELLELDKWANLWNWFDISNWLWY

CC1/85 control

4

---------------------------------------------------------------------------------

CC1/85, maraviroc

4

--------------------------------------------------------------------------------

CC1/85, vicriviroc

4

--------------------------------------------------------------------------------

CC1/85 control

16

---------------------------------------A--------------------------------------

CC1/85, maraviroc

16

---------------------------------------A--------------------------------------

CC1/85, vicriviroc

16

--------------------------------------------------------------------------------

  

gp 41 amino acid sequence

CC1/85

start

812                        850

IKIFINATALAVAEGTDRILEVLQRAYRAILHIPRRIRP

CC1/85 control

4

-----------------I-----------------------------------------------------

CC1/85, maraviroc

4

-----------------I-----------------V-----------C--------------------

CC1/85, vicriviroc

4

------------------------------------------------------------------------

CC1/85 control

16

-----------------I-----------------V----A-----C---------------------

CC1/85, maraviroc

16

-----------------I-----------------V-----------C-------------------Q

CC1/85, vicriviroc

16

------------------------------------------A----------Y---------------

  1. Residues are numbered according to the HXB2 gp120 sequence.